![]() Like vitamin K antagonists, these agents, as a class, carry a small risk for major bleeding events, which are associated with considerable morbidity and mortality and result in substantial economic burden Citation 3–7. Direct oral factor Xa inhibitors, such as apixaban and rivaroxaban, are used for the prevention of ischemic stroke, as well as for the prevention and treatment of venous thromboembolism Citation 1, Citation 2.
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